½»¸¶ÏÖ³¡ Ëæמ«×¼Ò½ÁƵÄÉú³¤ºÍ»ùÒò¼ì²âÊÖÒÕµÄÆÕ¼°£¬¼ì²âÏîÄ¿ÖÖÀà·±¶à£¬ÖØƯºóÒ»Ö±Ìá¸ß£¬¹Å°åµÄ¹ÜÀíģʽÄÑÒÔ˳Ӧ¶à±äµÄ¼ì²âÐèÇó£¬ÓÈÆäÊÇÔÚÑù±¾¹ÜÀí¡¢¼ì²âÁ÷³Ì¼à¿Ø¼°Ð§¹ûÆÊÎö·½Ãæ¡£ ÏêϸÌåÏÖΪ£¬²î±ð¼ì²âÏîÄ¿×ÔÁ¦ÔËÐУ¬È±·¦Í³Ò»¹ÜÀí£¬µ¼ÖÂ×ÊÔ´·ÖÅɲ»¾ù¡¢Î¬»¤±¾Ç®¸ß°º£»Ñù±¾´ÓÎüÊÕ¡¢´¦Öóͷ£µ½ÆÊÎöµÄÈ«Á´Ìõ×·ËÝÄÑÌ⣻ͬʱ£¬»ùÒò¼ì²â±¨¸æµÄ½â¶ÁÖØ´óºÄʱ£¬×¨ÒµÃż÷¸ß£¬ÏÞÖÆÁË·þÎñЧÂʺͻ¼ÕßÌåÑéµÄÌáÉý¡£ DA-genepliot×÷Ϊһ¿îʵÑéÊÒÕûÌå½â¾ö¼Æ»®£¬Í¨¹ýÕûºÏÉúÐÅÆÊÎöÁ÷³Ì¡¢Ñù±¾¼ì²âÐÅÏ¢»¯¹ÜÀí¡¢Ð§¹û½â¶Á¹¤¾ßµÈ¹¦Ð§£¬ÊµÏÖÁË´ÓÑù±¾ÎüÊÕ¡¢¼ì²âÖ´ÐС¢Êý¾ÝÆÊÎöµ½±¨¸æÌìÉúµÄÈ«Á÷³Ì×Ô¶¯»¯ºÍ±ê×¼»¯£¬½«ÎªºóÐøÏîÄ¿ÐÂÔöÓëºÏ×÷ÉîÈëÌṩԽ·¢¿ª·Å¼æÈݵÄƽ̨¡£
01 ʵʱ¸ú×ÙÑù±¾¼ì²â״̬ Ñù±¾¹ÜÀí½çÃæ
DA-genepliotʵÏÖÁ˼ì²âÏîÄ¿ºÍÑù±¾µÄË«Ïò¹ÜÀíÓ붯̬¼à¿Ø¡£¿Í»§¿ÉÒÔʵʱ¸ú×ÙÑù±¾¼ì²âµÄ״̬£¬»¹¿ÉÒÔƾ֤Ô¶ȡ¢ÐÇÆÚ£¬»ØÊ×ÆÊÎöÑù±¾Á¿µÄת±äºÍÏîÄ¿¼ìÕÉÁ¿µÄת±ä¡£
02 ÕûºÏÆÊÎöЧ¹û£¬Ò»¼ü³ö±¨¸æ Ñù±¾¼ì²âЧ¹û½â¶ÁÒ³Ãæ¼°±¨¸æÌìÉú
DA-genepliotʵÏÖÁ˶þ¼¶ÉúÐÅÆÊÎöÓëÈý¼¶ÁÙ´²ÆÊÎöµÄÕûºÏ£¬×öµ½¡°Ò»¼ü³ö±¨¸æ¡±¡£¿Í»§ÉÏ´«Ñù±¾ÐÅÏ¢±íºó£¬DA-genepliot¾ÙÐÐÑù±¾²âÐòÇéÐεÄʵʱ¼à¿ØºÍÏ»úÊý¾ÝµÄ×Ô¶¯ÆÊÎö£¬¶Ô¼ì²âµ½µÄ»ùÒòÍ»±ä¾ÙÐбäÒì·Ö¼¶¡¢ÓÃÒ©¡¢Ô¤ºó¡¢ÁÙ´²ÊÔÑéµÄ¹ØÁªÕ¹Ê¾£¬×îºóÒ»¼üÉúÉíÆÊÎö±¨¸æ¡£
03 ¸ß¸ºÔØÐÔÄÜ£¬×ÊÔ´¸ßЧʹÓà ÑùÌìÖ°ÎöÔËÐÐ״̬½çÃæ
Õë¶Ô»ùÒò²âÐòÊý¾ÝÁ¿ÖØ´óµÄÌص㣬DA-genepliotÅ䱸¸»×ãµÄÅÌËã×ÊÔ´£¬Èç¶à½¹µã¸ßÐÔÄÜ´¦Öóͷ£Æ÷¡¢´óÄÚ´æ¡¢´æ´¢×°±¸£¨100TB¼¶±ð´ÅÅÌÕóÁУ©£¬ÄÚÖøßÐÔÄÜÓÅ»¯·ÖÅÉϵͳ£¬¿Éƾ֤ÅÌËã×ÊÔ´×ÜÁ¿ºÍÏîÄ¿ÉêÇë×ÊÔ´Á¿¾öÒé±üÐÔÆÊÎöÊýÄ¿£¬ÊµÏÖ¸ºÔØƽºâÓë×ÊÔ´¸ßЧʹÓá£
04¡°×¨¼Ò½â¶Á¡±ÊµÊ±ÔÚÏß ÎªÌáÉýÑù±¾¼ì²â¼ÛÖµÓë¿Í»§ÌåÑ飬DA-genepliotÉèÖá°¼´Ê±×¨¼Ò½â¶Á¡±·þÎñ¡£mg±ùÇòÍ»ÆƹÙÍøÍøÕ¾×ÊÉîÒÅ´«ÆÊÎöÍŶÓʵʱÔÚÏߣ¬È·±£ÔÚ°ëСʱÄÚ¿ìËÙÏìÓ¦£¬ÌØÊâÊÇÔÚÓöµ½ÓÐÊý»òÖØ´ó»ùÒòÍ»±ä°¸Àýʱ£¬ÄÜÂíÉÏΪÁÙ´²Ò½Ê¦ÌṩÉî¶ÈÒÅ´«ÆÊÎö£¬Ç¿»¯ÁÙ´²¾öÒéµÄ¿ÆѧÒÀ¾Ý£¬Ëõ¶Ì»¼Õß»ñÈ¡¸öÐÔ»¯ÖÎÁƼƻ®µÄʱ¼ä¡£ 05 º£Á¿Êý¾ÝÖúÁ¦¿ÆÑÐת»¯ DA-genepliotµÄ½â¶ÁÊý¾Ý¿âÏÖÔÚÒÑÓµÓÐÁè¼Ý20ÍòÌõÍ»±ä½â¶Á¼Í¼£¬º¸ÇÁË1300¶àÖÖ»ùÒòÐÎò¡¢400ÓàÖÖ»ù´¡Ò©ÎïÐÅÏ¢¼°ÏìÓ¦400¶àÖÖ»ñÅú˳Ӧ֢¡¢600¶àÏîÓÃÒ©ÆÊÎö£¬ÕâЩÄÚÈÝÖÜÈ«°üÀ¨Á˾FDA/NMPAÅú×¼µÄÒ©Îï¼°ÆäÊÊÓùæÄ££¬²¢ÕûºÏÁËNCCN/CSCOµÈȨÍþÖ¸ÄÏÍƼöµÄÖÎÁƼƻ®¡£±ðµÄ£¬¸ÃÊý¾Ý¿âÆÕ±é½è¼øOncoKB¡¢COSMIC¡¢CIVIC¡¢PharmGKB¡¢ClinicalTrialsµÈרҵ×ÊÔ´£¬¶¯Ì¬×·×Ù²¢ÎüÄÉASCO¡¢WCLC¡¢CSCOµÈÖ÷Ҫҽѧ¾Û»áµÄ×îÐÂÑо¿Ï£ÍûÓëЧ¹û¡£DA-genepliot½«³ÉΪÖúÁ¦ÁÙ´²¿ÆÑеÄÇ¿ÓÐÁ¦¹¤¾ß£¬ÎªÓû§Ìṩ±ã½ÝµÄÊý¾ÝÍÚ¾òÓëÖ§³Ö·þÎñ¡£
δÀ´£¬mg±ùÇòÍ»ÆƹÙÍøÍøÕ¾ÁÙ´²»ùÒò×éÖÐÐĽ«»ùÓÚÇ°ÑصÄÉúÎïÐÅÏ¢ÊÖÒÕ¡¢È˹¤ÖÇÄÜËã·¨µÄÇ°½øºÍ¿Í»§¶ËµÄÌؼìÐèÇ󡢿ÆÑÐÐèÇó£¬Ò»Á¬Éý¼¶DA-genepliot£¬ÒÔ·þÎñ¿Í»§ÎªÖÐÐÄ£¬Ò»Ö±¿ª·¢Öª×ãÊг¡ÐèÒªµÄ²úÆ·£¬Íƶ¯¾«×¼Ò½Áƽâ¾ö¼Æ»®µÄÁ¢ÒìÓëʵ¼ù¡£